Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA.
نویسندگان
چکیده
منابع مشابه
Isoprenoid enzyme systems of silkworm. I. Partial purification of isopentenyl pyrophosphate isomerase, farnesyl pyrophosphate synthetase, and geranylgeranyl pyrophosphate synthetase.
Isopentenyl pyrophosphate isomerase, farnesyl pyrophosphate synthetase, and geranylgeranyl pyrophosphate synthetase were detected in cell-free extracts of Bombyx mori and were partially purified by hydroxyapatite and Sephadex G-100 chromatography. Two forms of farnesyl pyrophosphate synthetase were chromatographically separated. They were designated as farnesyl pyrophosphate synthetases I and I...
متن کاملIdentification and regulation of a rat liver cDNA encoding farnesyl pyrophosphate synthetase.
CR39 is a cholesterol-repressible rat liver cDNA previously isolated by differential hybridization (Clarke, C.F., Tanaka, R.D., Svenson, K., Wamsley, M., Fogelman, A.M., and Edwards, P.A. (1987) Mol. Cell. Biol. 7, 3138-3146). To precisely identify the function of CR39 a fusion protein was constructed that contained the amino-terminal region of the bacterial protein anthranilate synthetase fuse...
متن کاملA human testis-specific mRNA for phosphoribosylpyrophosphate synthetase that initiates from a non-AUG codon.
Two highly homologous subunits for phosphoribosylpyrophosphate synthetase are encoded by human X-linked genes, PRPS1 and PRPS2 (Taira, M., Kudoh, J., Minoshima, S., Iizasa, T., Shimada, H., Shimizu, Y., Tatibana, M., and Shimizu, N. (1989b) Somat. Cell Mol. Genet. 15, 29-37). These genes are expressed in most tissues, whereas an additional unique mRNA (1.4 kilobases) is present in the testes of...
متن کاملPurification and properties of phosphoribosyl pyrophosphate synthetase from rat liver.
Phosphoribosyl pyrophosphate synthetase has been purified extensively from rat liver. Gel filtration studies indicate that the enzyme is a complex of large molecular weight. On electron microscopy, stacking of enzyme molecules into long, linear aggregates is observed. The subunit molecular weight is 40,500, as measured by disc gel electrophoresis in sodium dodecyl sulfate. MgATP appears to be t...
متن کاملThe evolution of transcription-initiation sites.
Unlike the situation in prokaryotes, most eukaryotic messenger RNAs contain a moderately long 5' untranslated region (UTR). Such leader sequences impose a burden on eukaryotic genes by providing substrate for the mutational origin of premature translation-initiation codons, which generally result in defective proteins. To gain an insight into the expansion of 5' UTRs in eukaryotic genomes, we p...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1990
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.10.5.2315